The Japan Agency for Medical Research and Development (AMED) is at the forefront of Japan’s research into aging and longevity, supporting studies at institutions like the University of Tokyo, Juntendo University, and Keio University. These efforts focus on understanding and controlling the mechanisms behind aging, with an emphasis on clinical applications — According to the Korean Economic Daily, AMED’s approach combines government-led research with academic foundation studies, distinguishing it from the United States’ tech capital-driven model.

AMED’s Aging Projects and Clinical Applications

AMED’s aging projects extend beyond basic research to include long-term support for studies with clinical applications. According to the Korean Economic Daily, notable achievements include a GLS1 inhibitor study published in January 2021, a senescent cell-removing vaccine study in December 2021, and a clinical application candidate identification study on senolytics in May 2024. These studies are based on the hypothesis that aging-related diseases stem from the accumulation of senescent cells and chronic inflammation.

Japan is particularly strong in the area of senolytics, which selectively remove senescent cells. According to the Korean Economic Daily, this strength is attributed to the country’s long-standing accumulation of basic research leading to the discovery of candidate substances and the expansion of therapeutic approaches.

EA SPORTS FC™ 27 Amed Sportif Faaliyetler Player Ratings

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Comparative Approaches to Aging Research

The Korean Economic Daily highlights how Japan’s AMED model contrasts with the United States’ approach; While the U.S. relies heavily on big tech capital to expand global aging and longevity research, Japan combines government-led R&D with university-based basic research. This model allows for a more structured and systematic approach to developing treatments for aging-related diseases.

The University of Tokyo’s Nakajima Research Group, supported by AMED, has spent over 30 years tracking the mechanisms behind aging-related diseases. Their work includes developing a new method for the pure culture of senescent cells and screening genes essential for their survival, according to the Korean Economic Daily.