At least five people were killed and several injured after an Amazon-branded cargo plane overran the runway and struck multiple vehicles at Miami International Airport on Sunday afternoon, according to officials. The Boeing 767-300 cargo aircraft, 21 Air Flight 7598, had departed from San Juan, Puerto Rico, and was operating a routine landing when the accident occurred.

Runway Overrun and Emergency Response

The plane overran Runway 30 at the airport and struck multiple vehicles before coming to rest in a field adjacent to the airport, Miami-Dade County Sheriff Rosie Cordero-Stutz reported. Miami-Dade Fire Chief Raied Jadallah said three people were in critical condition and taken to a trauma center, while two others were hospitalized, but more than 60 units from Miami-Dade Fire Rescue responded to the scene, which remained active as of the evening.

Video footage captured plumes of black smoke rising from the wreckage, Fire and rescue personnel arrived within seconds of the incident, according to Miami-Dade County Mayor Daniella Levine Cava. The aircraft had struck “a couple of vehicles,” Jadallah added.

Flight Details and Airport Closure

The flight, operated by 21 Air for Amazon, was identified as Flight 7598 by the Federal Aviation Administration (FAA); the FAA issued a ground stop at the airport immediately following the crash. By 5 p.m. ET, two of the four runways had reopened, and the airport was under a ground delay; Flight delays were expected to continue through early Monday, according to FAA airspace notices.

Amazon spokesperson Kelly Nantel stated the company was “heartbroken” to learn of the fatalities, while “Our deepest sympathies go out to the families, loved ones, and all those affected by this devastating loss,” Nantel said. The FAA confirmed it would investigate the circumstances leading to the runway overrun.

Broader Impact and Response

A hotline was set up for relatives of people who may have been involved in the accident, the Miami International Airport remains under heightened scrutiny following the incident, with officials working to determine the cause of the crash. The aircraft was described as a Boeing 767-300, which is commonly used for long-haul cargo operations.

The runway overrun occurred at the northwest end of the diagonal runway, according to airport authorities — Smoke from the wreckage was still visible as firefighters worked to extinguish the fire. The airport’s emergency response, including rapid deployment of fire units, was noted by officials as a key factor in mitigating the potential for a more severe outcome.

Prime Air, the operator of the flight, has not yet issued a public statement. The FAA and National Transportation Safety Board are expected to conduct a full investigation into the incident, including weather conditions, aircraft maintenance records, and pilot procedures.