Lori Chavez-DeRemer. The Labor Secretary under President Donald Trump, has stepped down from her role to pursue a position in the private sector, as announced by White House communications director Steven Cheung in a statement. Cheung praised her work in protecting American workers and advancing fair labor practices, according to CNN.

Resignation Amid Internal Investigations

Chavez-DeRemer’s departure comes amid a turbulent tenure marked by internal investigations and controversy — According to CNN, she faced scrutiny from within the Department of Labor, with complaints about her conduct leading to an internal probe. The New York Times previously reported that her husband had been banned from the department’s headquarters due to sexual assault allegations, though a criminal investigation into the matter has since been closed.

In March. Two of her top aides were forced to leave amid an investigation into misconduct at the agency. Despite these challenges. Chavez-DeRemer expressed pride in her work, stating on X that she had been honored to serve in the Trump administration and advance the president’s mission to put American workers first, according to CNN.

Acting Secretary and Continued Focus on Workers

Keith Sonderling will serve as acting secretary of the Department of Labor, as announced by Cheung, while Sonderling expressed gratitude for the opportunity to serve and reiterated the administration’s commitment to prioritizing American workers, according to CNN.

The White House has not yet provided details on when Chavez-DeRemer’s departure will take effect, though CNN has requested further information. Her exit adds to a growing list of departures from the Trump administration, including the recent firing of Kristi Noem as Secretary of Homeland Security in early March 2026, according to Action Network.

Speculation on Next Cabinet Departures

Following Noem’s departure. Speculation has risen about who will leave the Trump administration next — According to Action Network, the odds for various cabinet members being the next to resign have been updated on the Kalshi betting market. Attorney General Pam Bondi. Who was fired by Trump on April 2, 2026, had a 12% chance of being the next to leave just two days before her departure.

Bondi’s dismissal was reportedly linked to her handling of Justice Department files related to Jeffrey Epstein and the DOJ’s failure to successfully prosecute several of Trump’s political enemies. According to Action Network, Bondi was informed of her ouster during a meeting with Trump in the Oval Office on April 1, 2026, just before his address to the nation on the Iran war.

While the focus of this article is on the resignation of Lori Chavez-DeRemer, the broader context of Trump’s cabinet instability is evident. With multiple high-profile departures already, the market for predicting the next departure has become a focal point for traders and observers alike, according to Action Network.